There is probably no other use case pushing storage infrastructure to its limits like High-Performance Computing (HPC). HPC use cases include far more than traditional academia. It is an umbrella term for many different industries like Energy, Media and Entertainment, Artificial Intelligence (AI), and Machine Learning (ML). In this white paper, StorONE discusses the requirements of these various industries and their sub-use cases to help IT ease the heavy burden of trying to architect an HPC storage infrastructure.